Antioxidant Evaluation of Some Coumarin Derivatives
نویسندگان
چکیده
The present study evaluated the antioxidant potential of 28 coumarin derivatives, using three antioxidant assays: DPPH inhibition, total reducing power and NO inhibition. Out of the tested compounds, the most active DPPH free radicals scavengers were the coumarin hydrazide derivatives. These substances were also the only ones among the investigated derivatives that exhibited a moderate reducing power of ferricyanide to ferrocyanide, but their activity was inferior to that exhibited by the reference substance (ascorbic acid). Most of the tested substances were moderate NO inhibitors. The activity of 4-methyl-7-methoxy coumarin was remarkable, exceeding the inhibitory potential of ascorbic acid.
منابع مشابه
Synthesis and Biological Investigation of some Novel Sulfonamide and Amide Derivatives Containing Coumarin Moieties
New sulfonamide and amide derivatives containing coumarin moieties; oxo-2H-chromen-sulfamoylphenylacetamides and oxo-2H-chromen-arylacetamides were synthesized starting from diverse 2-chloroacetamide derivatives and a wide range of coumarins. The structures of the obtained compounds were elucidated by IR and NMR spectra and also analytical elemental analysis. In the next step, the above mention...
متن کاملSynthesis and Biological Investigation of some Novel Sulfonamide and Amide Derivatives Containing Coumarin Moieties
New sulfonamide and amide derivatives containing coumarin moieties; oxo-2H-chromen-sulfamoylphenylacetamides and oxo-2H-chromen-arylacetamides were synthesized starting from diverse 2-chloroacetamide derivatives and a wide range of coumarins. The structures of the obtained compounds were elucidated by IR and NMR spectra and also analytical elemental analysis. In the next step, the above mention...
متن کاملMicrowave-assisted synthesis and antioxidant properties of hydrazinyl thiazolyl coumarin derivatives
UNLABELLED BACKGROUND Coumarin derivatives exhibit a wide range of biological properties including promising antioxidant activity. Furthermore, microwave-assisted organic synthesis has delivered rapid routes to N- and O-containing heterocycles, including coumarins and thiazoles. Combining these features, the use of microwave-assisted processes will provide rapid access to a targeted coumarin...
متن کاملDesign and Synthesis of Some Amino Coumarin Derivatives by Using Mild Catalyst
Coumarin possesses a number of biological activities like antimicrobial, anti-inflammatory, analgesic, antioxidant, anticancer, antimalarial etc. Coumarin belongs to a group of benzpyranes, which consist of a benzene ring joined to a pyran nucleus. In the present study amino derivatives bearing coumarin nucleus are synthesized from 7-hydroxy -4methyl coumarin by using mild catalyst, CAN which i...
متن کاملNovel coumarin–benzimidazole derivatives as antioxidants and safer anti-inflammatory agents
Inspired from occurrence of anti-inflammatory activity of 3-substituted coumarins and antiulcer activity of various 2-substituted benzimidazoles, novel compounds have been designed by coupling coumarin derivatives at 3-position directly or through amide linkage with benzimidazole nucleus at 2-position. The resultant compounds are expected to exhibit both anti-inflammatory and antioxidant activi...
متن کامل